Endogenous And Exogenous Antioxidants Benefits

Endogenous And Exogenous Antioxidants Benefits Despite the usefulness of oxidation reactions to life, it could also cause a great harm to humankind. Human beings have body that generates free radicals very continuously and these are always produced from the oxidation reaction that constantly takes place in living cells. Apart from the radicals that results from oxidation, some other ones are generated from immune cells to combat bacteria and viruses and also from ingestion, inhalation, and or absorption from our immediate environment during burning by sun or ultraviolet rays. Damage caused by free radicals includes aging, destruction of DNA and clogging of arteries. It is also believed that free radicals may play a role in cancer, strokes, and heart disease. Oxidative stress may also damage or kill cells. Free radicals cause damage to skins structural support and decrease its elasticity, resilience, and suppleness. Antioxidants stop the chain reactions of free radical, and inhibit other oxidation reactions. An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. There are two types of antioxidants: exogenous and endogenous. Exogenous antioxidants are antioxidants we get from our diet and endogenous antioxidants are made by our bodies. Endogenous antioxidants repair free radical damage on the inside by initiating cell regeneration; exogenous antioxidants repair some free radical damage from the outside on in by stimulating cell regeneration. The role of endogenous and exogenous antioxidants Exogenous antioxidants are antioxidants we get from our diet by eating antioxidant-rich foods and by taking supplements. Some well known examples of exogenous antioxidants are vitamins A, C and E. Even though exogenous antioxidants can be obtained from food sources, in our modern day world it is nearly impossible to get enough exogenous antioxidants from our diet to neutralize all of the free radicals generated. This is why antioxidant supplementation is so vital. Endogenous antioxidants are made by our bodies. Because they are produced by our own bodies and not obtained from food sources, endogenous antioxidants are far more potent than exogenous antioxidants. Endogenous antioxidants repair all of the free radical damage by initiating cell regeneration from the inside on out, whereas, exogenous antioxidants only repair some of the free radical damage from the outside on in by stimulating (not initiating) cell regeneration. There are five extremely powerful endogenous antioxidants. They are: Glutathione (GSH), Alpha Lipoic Acid (ALA), Superoxide Dismutase (SOD), Catalase and Coenzyme Q10 (CoQ10). Unfortunately, the bodys production of endogenous antioxidants declines as we age. For example, our glutathione levels decline about 10-15% per decade as we grow older. This decrease in endogenous antioxidants is found to be a strong factor in contributing to premature aging and degenerative diseases. There is more than enough studies to verify that by increasing our endogenous antioxidant cellular levels, such as our glutathione levels, we can greatly help prevent many age-related health issues and degenerative diseases like Diabetes, Alzheimers, Cancer, Heart Disease, and many other health concerns. (Curr Cardiol Rev.2008 Nov; 4(4):259-68.) (Kaneto et al, 1999) Sources of Antioxidants All plants produce antioxidants. Even meat, dairy products, and eggs contain some antioxidants, which mainly come from the nutrient-rich plants the animals fed on. Plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, and vitamin E as well as enzymes such as catalase, superoxide dismutase and various peroxides. Antioxidants protection against diabetes Diabetics have high levels of oxidative stress, which basically means too many free radicals and not enough antioxidants to neutralize them. It would be beneficial for anyone suffering from Diabetes to increase their antioxidant supplementation. Glutathione, being the master antioxidant, would naturally be the best choice. Furthermore, inflammation leads to and contributes to insulin resistance. Glutathione, on top of being the most potent antioxidant, is also a powerful ant-inflammatory. Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately in diabetes à ¢Ã¢â€š ¬Ã‚ ¦.Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to à ¢Ã¢â€š ¬Ã‚ ¦.development of insulin resistance. These consequences of oxidative stress can promote the development of complications of diabetes mellitus. (Wiley 2003) à ¢Ã¢â€š ¬Ã‚ ¦there is evidence for increased oxidative stress in diabetesà ¢Ã¢â€š ¬Ã‚ ¦.With regard to diabetes, antioxidantsà ¢Ã¢â€š ¬Ã‚ ¦supplementation have been shown to be beneficial. Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality. (Vega-Lopez et al, 2004) Researchers at the University of California, San Diego (UCSD) School of Medicine have discov ered that inflammationà ¢Ã¢â€š ¬Ã‚ ¦leads to insulin resistance and Type 2 diabetes. Science Daily (Nov. 7, 2007) Antioxidants protection against cancer, coronary heart disease and stroke Apples, and especially apple peels, have been found to have a potent antioxidant activity and can greatly inhibit the growth of liver cancer and colon cancer cells (Wolfe et al. 2003) (Eberhardt et al. 2000). The total antioxidant activity of apples with the peel was approximately 83 ÃŽÂ ¼mol vitamin C equivalents, which means that the antioxidant activity of 100 g apples (about one serving of apple) is equivalent to about 1500 mg of vitamin C. However, the amount of vitamin C in 100 g of apples is only about 5.7 mg (Eberhardt et al.2000). Vitamin C is a powerful antioxidant, but research shows that nearly all of the antioxidant activity from apples comes from a variety of other compounds. Vitamin C in apples contributed less than 0.4% of total antioxidant activity. (Liu et al. 2001) Prospective studies suggest that people with high intakes of fruit and vegetables or blood antioxidant concentrations (Pandey et al. 1995) (Enstrom et al. 1992) in the highest quintile of the distribution have low risks of epithelial cancers,( Steinmetz and Potter 1991) coronary heart disease,(Gaziano et al.1995) and stroke. At least 10 prospective studies have shown that high intakes of fruit and vegetables confer protection against cancer, cardiovascular disease, and stroke (Steinmetz and Potter 1991) (Gillman et al.1995) Abundant evidence proves the role of virgin olive oil in protecting against cardiovascular disease. While it has long been known that olive oil helps decrease total cholesterol and low-density lipoprotein (LDL) levels (Covas et al.2006) new research is shedding light on its additional cardiovascular benefits. According to the Food and Drug Administration, Eating about 2 tablespoons of olive oil daily may reduce the risk of coronary heart disease. To achieve this possible benefit, olive oil is to replace a similar amount of saturated fat and not increase the total number of calories you eat in a day.(Fito et al. 2005). Scientists have proposed that several constituents of olive oil may be responsible for its anti-cancer effects. These include its anti-oxidant polyphenols as well as the lipid oleic acid, which is highly resistant to peroxidation. (Owen et al. 2004) However, there are a number of dietary antioxidants that have been identified that would help us to understand how the antioxidants function, and some are still in the process of development and testing. (Uddin and Ahmad 1995) A group of chemists at University of Scranton in Pennsylvania says that adding a mixture of antioxidants to sunscreen may help enhance protection of cancer. In animal studies, they found that a mixture of various topical antioxidants was more effective than single antioxidants in preventing the formation of skin tumors induced by ultraviolet light. In another study, the same research team found that black tea, green tea, grape seed and cranberry extracts were all promising antioxidants for fighting skin cancer when applied topically. Both studies were presented at the 229th national meeting of the American Chemical Society, the worlds largest scientific society, in San Diego on March 14, 2005. Conclusion We need to eat a healthy diet with a variety of fruits and vegetables. We cannot depend on any single super antioxidants, a variety of antioxidants are needed. Currently only antioxidants from food compounds with vitamins (vitamins A, C and E) have been proven with antioxidant efficacy. Environmental factors that produce free radicals could be avoided. In numerous epidemiological studies, apples have been associated with a decreased risk of chronic diseases such as cardiovascular disease, cancer, and asthma. In vitro and animal studies have demonstrated that apples have high antioxidant activity, can inhibit cancer cell proliferation, decrease lipid oxidation, and lower cholesterol, potentially explaining their role in reducing risk of chronic disease. The potential health benefits of apples are numerous. Regular consumption of fruits and vegetables, including apples, as part of a healthy diet may aid in the prevention of chronic disease and maintenance of good health.

Coroperate Social Responsibility

Corporate Social responsibility Introduction A few years ago firms only goal was to gain economic profit from their businesses. In recent times it has been discussions if economic profit are the only reason for businesses to exist (Kilotons 1991) In modern society the belief that businesses have responsibilities against the society they operate in have grown bigger, but there are still people and organizations who believe that gaining economic profit from their business are the only thing they have to be concerned about (Chant 2013).The purpose of this essay is to discuss and compare the different viewpoints of corporate social responsibility (hereafter referred to as CARS) and the key issue is to see why corporations and their management should be concerned with CARS. The paper will start by explaining what CARS is and how businesses can gain profit from applying CARS. Thereafter the counterargument, that business doesn't have any other responsibilities then gaining profit, will be presented. An example of good CARS-work will thereafter be demonstrated.The relationship between ethics in business will also be discussed. Different views of CARS There are many different definitions of what corporate social responsibility is but one ay to look at it is that corporate responsibility is used to describe the work that companies do voluntarily that has a positive impact on society, the environment or the economy (Shill, Apothecary ; Kansas 2010). CARS is supposed to help businesses to behave ethically and gain economic profit and at the same time helping to solve social issues (Chant 2013).Not only are CARS good for the society and the people in it but also for the stakeholders of the company. CARS can change stakeholders purchase behavior, employment seeking and also investment. Over mime CARS can also help the company to build a stronger brand and in that way also gain an economic profit (Shill, Apothecary ; Kansas 2010). In recent times a lot of critiques have been pointed to CARS. The counterargument meaner that business only responsibility against the society is to gain economic profit and only do what the business was created to do (Chant 2013).Many opponents against CARS say that businesses only should use their resources and engage in activities that are designed to increase profits so long as it stays within the law (Kilotons, 1991). Why corporate social responsibility? The question is if businesses and corporations have a social nature and responsibility or not? My own answer to this question is that businesses, in the modern society, is of social nature and have responsibilities against the society. Corporations and businesses are a big part of our society and what they do make a big impact on people, environment and also how other business act.I would like to compare it with people walking on the street and don't put their rubbish in the garbage bins. I believe that almost everyone thinks that it would be ethically wrong not to put t heir rubbish in the bins. If everyone throws their rubbish on the street the society and community would not have looked nice and people would care less about, in this case, the environment because no one else does. My point of view is that it reflection of the people in it and so are the corporations and business (Chant 2013).It's understandable that some corporations think it is unnecessary to implement CARS and that it only will cost them money that they won't get back. To demonstrate how businesses can gain economic advantages from CARS I will use a Swedish company ‘KEA. KEA is a big home decoration company that operates all over the world and ton is one of their most important raw materials. The company want all cotton used in their products to come from sustainable productions. By using the better cotton initiative they can help reduce environmental and social impacts.They have also proved that this initiative can help KEA to offer competitive priced products that satisf y customers' needs and also helps the company to reach one of their ambitions to provide responsibly sourced products (CARS: Sweden leads by example in corporate responsibility 2013) With that said, my point is that many companies have to look ore on the output they can gain from CARS and not so much on the input. Conclusion There are many ways of looking at and understand CARS and my point of view in this paper is that CARS is a good thing and that corporations and businesses can gain both social and economic profits from it.On the other hand it can be difficult to measure performance of CARS and to compare business with each other (Chant 2013). But maybe comparing and competitiveness is not necessary as in economical ways. Maybe CARS can be Just a question of good ethics, something as obvious as throwing rubbish in the garbage bin or pay your employees' salary in time. Is that a realistic goal? Probably not, because it takes that CARS belong to some sort of common sense if that's going to happen.The important thing for businesses to understand is that CARS should be a part of their business strategy and goal. The modern world is growing and businesses have to keep up with the changes in the environment around them. People are getting more knowledge about ethics and culture and that's why it's getting more important for businesses and their management to apply it in to their strategy. Maybe people are going to choose one supermarket in front of the other cause the first one didn't care about the ethical issues with food production.

Prop 34: the Death Penalty

The Death Penalty, also known as Capital Punishment is a world wide controversial issue. Should the death penalty be repealed and replaced with life imprisonment without possibility of parole? California voters on Tuesday rejected a ballot measure that would have repealed the state's death penalty. Supporters against Prop 34 claim that California is broke and taxpayers would pay at least $50,000 annually, giving lifetime healthcare and housing to killers who tortured, raped, and murdered children, cops, mothers and fathers. A yes on Prop. 4 states that no offenders would be sentenced to death under state law. Offenders who are currently under a sentence of death would be resentenced to life without the possibility of parole. The state would provide a total of $100 million in grants to local law enforcement agencies over the next four years. I strongly agree with a vote yes on Prop. 34. The death penalty isn’t an effective way to prevent or reduce a crime. Not only does this no t prevent future crimes and murders, but sometimes the death penalty is applied unfairly to innocent people.Evidence has shown that more than 100 innocent people have been sentenced to death in the United States and some have been executed. Prop. 34 means that the state of California will never execute an innocent person. Franky Carrillo was 16 when he was arrested and wrongly convicted of murder in Los Angeles; it took 20 years to show his innocence. Judge LaDoris Cordell, from Santa Clara said â€Å"If someone’s executed and later found innocent, we can’t go back. † I agree with this judge because what if later we find evidence that the offender is innocent there no way we can bring someone back to life.So then again who has the right to take the life of a human, when God is the one who decides when our time on earth has come to an end. Life without parole would be less expensive than the death penalty. California’s death penalty is too costly and is ha rdly used. Only 13 people have been executed since 1967 and no one since 2006. Prisoners are put to death row but die of old age before they make it to there punishment. We waste millions of tax dollars on special housing for these inmates, when they just sit around doing nothing.To me it makes more sense to keep a killer in a prison for the rest of his/her life until they die. An impartial study found California will save nearly $1 billion in five years if we replace the death penalty with life in prison without possibility of parole. The savings would come from eliminating lawyers’ fees and special death row housing. California is broke and Prop. 34 will save us money. We all know that killing another person is the most evil crime that one can commit.But it seems that our government is being hypocritical when it states that capital punishment is allowable because, after all, the criminal did murder an innocent victim, and therefore should be killed. This is known as the â⠂¬Å"eye for an eye, and tooth for a tooth theory. † Of course, if we used this system all the time, there would be no need for laws. The majority of countries in Western Europe, North America and South have abandoned capital punishment. Why is it that the United States remains a user of capital punishment?The death penalty is the ultimate cruel, inhuman and degrading punishment. It denies criminals their natural born right to life. The death penalty should be abolished because it has never been shown to lower crime rates or stop serial killers from killing. It costs far more to execute a person than to keep him or her in prison for life. Capital punishment is against the humanity, we can find other alternatives to it. As Voltaire once said, â€Å"It is better to risk saving a guilty man than to condemn an innocent one. †

Soy Protein Substitutes in Meat Products essays

Soy Protein Substitutes in Meat Products essays For the past couple of year the number of Americans that are overweight keeps increasing. Today fifty five percent of Americans are overweight. Because of this unhealthy trent the media, researchers, doctors and specialists have been educating and informing the population that eating a healthy diet is beneficial for the body in many ways. As a result of the growing awareness of the benefits of eating a healthy diet today's consumers have become more health-conscious than ever before. When researchers and scientists talk about a healthy diet they emphasize on cutting back on a diet high in animal fat, which increases one's risk for osteoporsis according to a study done at the University of California in San Francisco (shape magazine Nov. 2001) and focusing on a plant-based diet, which has many health benefits such as reducing the risk of heart disease, protecting against breast and prostate cancer, and helps in the prevention of osteoporosis. The focus on a plant-based diet has sti mulated the interest in soy products in the United States. Dana Jacobi states that soy is a complete vegetarioan protein derived from soybeans that has been consumed by people in Asian countries for thousands of years. This protein is considered "complete" because it contains all eight amino acids (protein building blocks) that are essential (cannot be made by the human body) to maintain healthy cells in the human body. "Recently soy has been gaining recognition and popularity as the American population learns more about its potential health benefits. In Octover of 1999 the Food and Drug Administration (FDA) approved the use of the "heart healthy" claim on soy protein products." The FDA put this claim on soy because it can reduce the risk of heart disease, which is the leading cause of deaths in the United States, can help protect the immune system, ward off heart attacks, strokes, osteoporosis, diabetes, and kidney disease. Soy is also an excellent sou...

Issue 1 Example

Issue 1 Example Issue 1 – Article Example HUMAN RESOURCE Lecturer’s Affirmative action- equal employment opportunity compliance Human resource office has the responsibility for implementation and development of affirmative action as well as equal employment opportunities compliance. They are committed to fostering an equitable, friendly as well as a diverse conducive environment where all staff members in a work place have an ability of achieving work life balance despite of their race, gender, age, faith, medical condition, sexual orientation and expression. Affirmative action is not a misnomer; rather it can be considered as firm actions that protect human resource at the work place (Crosby, Iyer, & Sincharoen, 2006).Current state of EEOC regulationsIt is not lawful to discriminate any individual in regards to promotion, transfer, performance, training, wage benefits or any employment privilege due to certain characteristics. Managers and employers need to adopt the best practices to reduce such instances of employe e’s discrimination as address the challenges facing equal employment opportunities (North-Samardzic & Gregson, 2011). According to the current guidelines employees, should not be discriminated based on their region, race, color, sex or origin. According to the guidelines race, discrimination ought to occur if an individual is subjected racial jokes, offensive comments, and ethnic slums on the basis of the person color or race. The guidelines prohibit against sex based wage discrimination, protect elderly individuals, prohibit discrimination against disabled and qualified persons and in case of any discrimination, it advocates for monetary damages charges. It also prohibits the discrimination of employment on the basis of the genetic information on the employee or applicant. The guidelines prohibit against medical state, pregnancy and childbirth discrimination (Kenney, 2004). Therefore, employers and managers need to understand and act in regards to the EEOC regulations to enh ance equal employment practices.ReferencesCrosby, F. J., Iyer, A., & Sincharoen, S. (2006). Understanding affirmative action. Annual Review of Psychology, 57, 585–611. doi:10.1207/s15324834basp1501_2Kenney, S. J. (2004). Equal employment opportunity and representation: Extending the frame to courts. Social Politics. doi:10.1093/sp/jxh027North-Samardzic, A., & Gregson, S. (2011). Commitment or Even Compliance? An Australian University’s Approach to Equal Employment Opportunity. Relations Industrielles-Industrial Relations, 66, 279–301.

Estimating a Multiple Regression Model (The impact of Consumption and Statistics Project

Estimating a Multiple Regression Model (The impact of Consumption and Investment on the GDP in Qatar (1990- 2013)) - Statistics Project Example Considering the topic selected the impacts that consumption and investment have on the GDP covers a wide range of economic aspects. These range from all activities that involve investing and all those that relate to consumption. The consumption aspect consolidates all consumption needs that range from consumption of oil products and other products. Understanding these and the employment of graphs will help one understand the impacts that each has had on the growth of the country for the years under consideration that is 1990 to 2013. The study covers these and details the description of the data, development of estimates, the discussion of the results and a conclusion that aims at creating a summary of the study and indicating the different achievements over the study conducted. Considering the data identified, one learns that the consumption is reflected as the expenditure. It covers both the government expenditures and the expenditures of the different households. Combining the two results to the expenditure for the economy, which is analyzed in the work below? Understanding this helps in understanding the impact that the expenditure aspect had on the GDP for the different years under consideration. In the data collected, the consumption is provided in the percentage terms and in billions of Qatar’s local currency. These provided are as obtained from an online source on Qatar economic statistics and indicators. The data collected on the different investment aspects also provides information with regard to the investment opportunities for the country and their impacts to the economic performance of Qatar. Understanding this helps one understand the actual performance of the economy with the investments that the country engages in accounted for the GDP. The data collected on the GDP is also obtained from the same website and

Introduction to computing Essay Example | Topics and Well Written Essays - 3000 words

Introduction to computing - Essay Example f software programs that run on a much deeper level than these surface uses that are essential to the usability and accessibility of any of these other programs. This type of software is called system software, without which the computer would be a nearly useless collection of plastic, metal and wires. This software governs everything from how the computer stores and interprets data to how it is analyzed and accessed and eventually displayed on the screen for user input. Additionally, how the computer responds to user signals is also managed by system software in operations that are generally never seen or even imagined by the end user. To understand how this works, it is necessary to understand the difference between the shell and the kernel embedded in the operating system as well as the main features of graphic user interfaces as opposed to command line or human/computer interfaces, ending with a look at some of the more common programs such as Unix, Linux and Windows Vista. A shell is the interface program that allows a user to communicate with the computer. Like the shell of a turtle or crustacean, the shell can be viewed as the outermost layer of the computer’s operating system. â€Å"Shells incorporate a programming language to control processes and files, as well as to start and control other programs† (â€Å"Chapter 11†, 1997). There are various ways in which a shell acts to facilitate information transfer between the user and the computer including providing the necessary prompts for user input, translating that input into language that the computer can understand and acting to turn any output from the computer into usable information back out to the user. This process can take place either through information transferred through the use of a keyboard or through the execution of a set of commands contained in a file called a shell script. â€Å"When you log in to the system, the system locates the name of a shell program to execute. Once executed,